This volume—Volume 34 of the Translational Epigenetics series—offers a comprehensive examination of how epigenetic mechanisms operate distinctly across different organ systems in both health and disease. Edited by Dr. Chandra S. Boosani and Dr. Ritobrata Goswami, the book synthesizes foundational concepts, organ-specific case studies, and translational applications for precision therapies. It delineates unique epigenetic signatures—from DNA methylation and histone modifications to non-coding RNAs—and explores their roles in stemness, proliferation, apoptosis, necrosis, immune modulation, and drug response. With contributions from leading experts, this work not only highlights mechanistic insights but also directs attention toward biomarkers and therapeutic targets that can revolutionize organ-targeted treatments. 📚🔬
Overview of the Book
Epigenetics in Organ Specific Disorders was published in December 2022 by Academic Press (Elsevier) as the first edition of Volume 34 in the Translational Epigenetics series. The paperback edition spans 666 pages and is available under ISBN 978-0-12-823931-5 (paperback) and ISBN 978-0-12-823932-2 (eBook). Selected for Doody’s Core Titles® 2024 in Clinical Genetics, this volume underscores its relevance for translational and clinical research communities.
Editorial Team and Contributors
「Chandra S. Boosani」, PhD, Assistant Professor at Pacific Western University School of Health Sciences, specializes in anticancer protein development and epigenetic drug mechanisms. His expertise includes in vivo drug testing and sequencing data analysis.
「Ritobrata Goswami」, PhD, Assistant Professor at the Indian Institute of Technology Kharagpur’s School of Bioscience, brings deep insight into molecular biosciences and genomic regulation.
Collectively, chapter contributors represent leading researchers in genetics, molecular biology, oncology, cardiology, neurology, pathology, physiology, and bioinformatics.
Scope and Objectives
This book aims to:
「Define core epigenetic mechanisms」—such as DNA methylation, histone acetylation/deacetylation, chromatin remodeling, and non-coding RNAs—in an organ-specific context 🔍.
「Contrast normal versus disease-associated epigenetic landscapes」 across tissue types, elucidating how similar molecular tools yield divergent phenotypic outcomes in liver, heart, brain, kidney, and other organs 🍃🫀🧠.
「Bridge mechanistic insights with translational applications」, identifying biomarkers and epigenetic targets for precision drug discovery and combination therapies 💊🔑.
Key Themes and Chapters
Epigenetic Mechanisms in Normal vs. Disease States
「Introduction to Epigenetic Mechanisms」 lays the groundwork by explaining how stable, heritable DNA and histone modifications regulate gene expression without altering nucleotide sequences.
「Epigenetic Signatures in Stem Cells」 examines pluripotent and mesenchymal stemness, highlighting how methylation patterns maintain self-renewal capacity and differentiation potential 🌱.
Organ-Specific Epigenetic Signatures
「Cell-Cell and Cell-Matrix Interactions」 mediated by histone deacetylases reveal how tissue architecture and microenvironment shape gene regulation 🧬.
「Tumor Suppression and Cell Cycle Control」 focuses on DNA methyltransferases and histone deacetylases in organ-specific oncogenesis, offering insights into cancer epigenetics across liver, breast, and prostate tissues 🦠 ❌.
「Immune Regulation and Phenotype Switching」 explores how epigenetic mediators govern immune cell differentiation and function in organ-specific inflammatory disorders 🛡️.
Translational Applications and Drug Discovery
「Current Epigenetic Drugs and Targets」 reviews FDA-approved and experimental agents—HDAC inhibitors, DNMT inhibitors—and their organ-targeting potential 💉.
「Prospects of Combination Therapies」 discusses synergistic approaches that pair epigenetic drugs with chemotherapy, immunotherapy, or targeted biologics for enhanced efficacy 🎯.
Significance for Students and Researchers
For 「students」, this volume serves as both a foundational text and a platform for critical thinking about how epigenetic modifications can diverge across tissues, promoting interdisciplinary learning in biology, chemistry, physics, and data science. For 「researchers」, the detailed case studies and translational insights provide actionable knowledge on biomarker identification, therapeutic target validation, and experimental design—catalyzing novel research projects in precision medicine and organ-specific therapeutics.
Conclusion
In sum, Epigenetics in Organ Specific Disorders is an indispensable resource that marries rigorous mechanistic analysis with translational relevance. With its breadth of topics, authoritative editorials, and forward-looking drug discovery perspectives, the book empowers a new generation of scientists to decode organ-specific epigenetic landscapes and to pioneer tailored therapeutic strategies. Happy reading and discovering! 🎓🔍
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