Clinical Chemistry By David White

Introduction to Clinical Chemistry

I am pleased to introduce 「Clinical Chemistry」—a comprehensive and authoritative textbook, first published in 2016 by Garland Science (Taylor & Francis) and authored by David White, Nigel Lawson, Paul Masters, and Daniel McLaughlin. This text, spanning approximately 604 pages and richly adorned with illustrative figures, stands as a seminal resource in the disciplines of chemical pathology, clinical biochemistry, and laboratory medicine.

Authors’ Scholarly and Professional Credentials

• 「David White, BSc, PhD, DSc」 – Completed his PhD in Physiological Chemistry at the University of Birmingham and advanced through postdoctoral studies at Johns Hopkins Medical School. He later became Associate Professor and Reader in Medical Biochemistry at the University of Nottingham, earning a DSc in 1998. He has significant experience teaching both bioscience and medical students, supervising PhD candidates, and serving as an external examiner. He also directed Academic Affairs at Nottingham’s Graduate Entry Medical School.

• 「Nigel Lawson, BSc, PhD, Clinical Biochemist」 – Obtained his BSc in Biochemistry (University of Sheffield) and PhD at Nottingham. He served as Consultant Clinical Biochemist at Nottingham City Hospital and Clinical Director for Pathology at Derby. A Fellow of the Royal College of Pathologists, Lawson contributed substantially to clinical chemistry training and examination in the UK.

• 「Paul Masters, MD」 – Trained in Medicine at Leeds, with a BSc in Chemical Pathology. He transitioned into postgraduate training and served as Consultant in Chemical Pathology and Metabolic Medicine from 1997.

• 「Daniel McLaughlin, Academic Educator」 – A long-standing medical educator at Nottingham and Durham Universities, he holds senior administrative and teaching roles and is recognized as a Senior Fellow of the UK Higher Education Academy.

Scope and Structure of the Text

Comprehensive Coverage

This textbook addresses 「clinical chemistry」 in the broadest and most impactful terms. It explores biochemical and physiological interrelations among molecules, tissues, and organs within the context of disease—clearly presenting the role of laboratory testing in diagnosis, disease monitoring, and patient management.

Analytical Techniques and Quantitative Laboratory Practice

The authors incorporate detailed discussions on analytical methodologies such as immunoassays and delve into how these techniques serve clinical practice.

Interdisciplinary Contextual Integration

While firmly rooted in clinical biochemistry, Clinical Chemistry integrates relevant content from 「haematology, radiology」, and 「microbiology」 where clinically necessary, thereby offering a multidimensional understanding of disease processes.

Adoption of SI and Non-SI Units

The textbook consistently employs 「Standard International (SI) units」, while also providing non-SI equivalents when used in clinical settings, ensuring clarity and practical relevance for a global readership.

Detailed Table of Contents

The book’s structured progression through key topics helps guide readers methodically through complex material. Notable chapters include:

1. Laboratory Medicine – An Introduction
2. Glucose
3. Liver
4. Kidney
5. Sodium and Water
6. Potassium
7. Acid–Base Disorders
8. Hypertension
9. Calcium, Magnesium, and Phosphate
10. Iron
11. Endocrine Tissues
12. Pregnancy
13. Muscle
14. Gastrointestinal Tract
15. Cerebrospinal Fluid and the Nervous System
16. Heme Biosynthesis and Porphyrias
17. Uric Acid and Purine Metabolism
18. Plasma Lipids and Lipoproteins
19. Disorders of Immunoglobulins and Complement
20. Tumor Markers
21. Therapeutic Drug Monitoring
22. Poisons and Drugs of Abuse
23. Inborn Errors of Metabolism
24. Vitamins, Essential Fatty Acids, and Trace Elements
25. Clinical Chemistry in the Acutely Ill Patient This structure reflects both foundational and advanced themes, progressing from basics to more complex and clinically urgent circumstances.

Conclusion

In conclusion, 「Clinical Chemistry by White, Lawson, Masters, and McLaughlin」 stands as a meticulously crafted, academically rigorous, and clinically relevant text. Spanning foundational topics to state-of-the-art clinical challenges, it is an indispensable resource for students, educators, clinicians, and researchers alike. Its comprehensive scope, methodological clarity, and interdisciplinary integration ensure its lasting utility in the field of laboratory medicine. Whether you seek to deepen your biochemical understanding, prepare for professional exams, or inform clinical practice, this volume is an excellent companion on that journey.

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Clinical Chemistry

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