Frontiers in stem cell and regenerative medicine research, Volume 1, Atta- ur Rahman; Shazia Anjum

Introduction

Frontiers in Stem Cell and Regenerative Medicine Research, Volume 1 (2015) unfolds as a significant scholarly compilation, expertly edited by 「Atta-ur-Rahman」 and 「Shazia Anjum」. Published by Bentham Science Publishers, this volume synthesizes state-of-the-art reviews addressing foundational and translational themes in the dynamic realm of stem cell and regenerative medicine. With ISSN identifiers (Print: 2467-9593; Online: 2352-7633) and ISBNs (Print: 978-1-60805-995-9; Online: 978-1-60805-994-2), the work is readily accessible through standard library and digital platforms.

Purpose and Scope

The volume serves as a thoughtfully curated collection of expert reviews covering:

• 「Safety assessment of mesenchymal stem cells (MSC) in musculoskeletal implantation」
• 「Strategies to improve immune reconstitution following hematopoietic stem cell transplantation」
• 「Alternative biomaterial substrates for human embryonic stem cell (hESC) culture」
• 「Regenerative medicine applications for the cornea and ocular surface」

These chapters collectively form a foundational reference for students and researchers alike, delivering both mechanistic depth and translational relevance in these high-impact areas.

Detailed Chapter Overview

1. Safety Assessment of MSC in Musculoskeletal Implantation

Authors: Greg Asatrian, Angel Pan, Michelle A. Scott, Aaron W. James (pp. 3–29) This chapter critically reviews current laboratory methodologies for evaluating MSC safety in bone, cartilage, and muscle implantation models. Highlighting gaps in practice, the authors note that fewer than one-third of studies assess proliferation or local inflammation, and that many experiments span less than two weeks—insufficient to capture long-term adverse effects such as sarcomagenesis or tumorigenesis. The authors propose practical, preliminary guidelines to standardize safety protocols and support translation from animal models to human clinical applications.

2. Strategies to Improve Immune Reconstitution Post-HSCT

Authors: Guy Klamer, Sylvie Shen, Ning Xu, Tracy A. O’Brien, Alla Dolnikov (pp. 30–64) This comprehensive review analyzes the challenges in immune reconstitution following hematopoietic stem cell transplantation (HSCT). Chemotherapy and conditioning regimens often impair thymic function, increasing susceptibility to infections and relapse. The authors explore therapeutic strategies, including cytokine administration (e.g., IL-2, IL-7, IL-15), growth factors, hormonal modulation, adoptive T-cell therapies, and pharmacological pathway manipulation (e.g., Wnt/Wnt-GSK3β). Together, these avenues present a multifaceted approach to restoring immune competence and preventing post-transplant complications.

3. Biomaterial Substrates for hESC Culture

Authors: Deepak Kumar, Ying Yang, Nicholas R. Forsyth (pp. 65–91) This chapter explores advanced nanofibrous substrates as innovative platforms for hESC expansion and directed differentiation. Designed to mimic native extracellular matrix nanoarchitecture, these substrates offer structural cues that influence cell behaviour, enhancing both proliferation and lineage-specific differentiation. The authors argue these biomaterial innovations hold promise for future clinical and tissue-engineering applications involving human embryonic stem cells.

4. Corneal and Ocular Surface Regenerative Medicine

Authors: Maria P. De Miguel et al. (pp. 92–138) This authoritative review delves into innovations in corneal repair and ocular surface regeneration. The cornea’s complex architecture—comprising multiple cellular and acellular layers—makes transplantation challenging, particularly due to limited donor availability and immune rejection. The chapter surveys bioengineered corneal constructs using scaffolds and autologous stem cells, with an emphasis on limbal stem cells (LSCs) and novel extraocular stem cell sources. These approaches are poised to revolutionize corneal therapy by enabling functional, immune-compatible, and reproducible treatments.

Significance for Students and Researchers

This volume stands as an essential compendium for learners and practitioners in regenerative biology, tissue engineering, and clinical translation. It addresses critical questions such as:

• How robust and safe are current MSC implantation strategies?
• What molecular and cellular interventions can accelerate immune recovery post-HSCT?
• How might engineered biomaterials advance hESC culture and differentiation?
• What emergent therapies can circumvent limitations in corneal transplantation?

By interconnecting these themes, the volume equips its readership with both conceptual frameworks and practical insights—empowering the design of future experiments, translational protocols, and interdisciplinary research.

Conclusion

Frontiers in Stem Cell and Regenerative Medicine Research, Volume 1 is a meticulously assembled and intellectually enriching resource. It bridges fundamental science and clinical promise, offering readers:

• In-depth reviews of safety, immune recovery, stem cell culture, and ocular regeneration
• Critical analysis that highlights current limitations and future directions
• A scholarly foundation for early-career researchers and established professors alike

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Frontiers in stem cell and regenerative medicine research

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